Chapter 15 - Clinical Corner

Your patient is a 35-year-old male who presents with a history of infections. These infections are due primarily to staphylococcal and streptococcal pathogens. His blood work shows a high titer of antibody against staphylococci and streptococci but he is currently infected with a strain of Neisseria. Further evaluation of his blood work indicates he has no titer against these organisms and also that he has little to no C3 protein in his blood. As part of his history he has told you that his father was also prone to repeated infections.

A. How will you explain his situation to him?

B. Should he be put on broad-spectrum antibiotics?

C. What do you tell him if he asks whether he will continue to have repeated infections?



Mr. Edison is recovering from a kidney infection. He has been receiving antibiotic therapy and his symptoms have diminished markedly. He has returned to the clinic because he has noticed blood in his urine. The doctor tells Mr. Edison that in some cases the response to an infection can have side effects that are as bad as the infection. After the doctor has left, Mr. Edison asks you to explain what the doctor meant.

A. What would you tell him?

B. Which of the innate responses would be the most involved in this?